An experiment was conducted at College of Agriculture, Nagpur to study the effect of terminal bud nipping and salicylic acid spray on growth and yield of sesame during kharif season of 2016-17. The experiment was laid out in Split Plot Design with two terminal bud nipping treatments viz., Na (no terminal bud nipping) and Ni (terminal bud nipping at 35 DAS) as main plot and five salicylic acid spray treatments viz., So (no spraying), Si (50 ppm spray of salicylic acid at 35 DAS), S2 (50 ppm spray of salicylic acid at 35 and 50 DAS), S3 (100 ppm spray of salicylic acid at 35 DAS) and S4 (100 ppm spray of salicylic acid at 35 and 50 DAS) as sub plot treatments, and were replicated thrice. The results of the study indicated that the terminal bud nipping at 35 DAS and 100 ppm spray of salicylic acid at 35 and 50 DAS were recorded higher growth, yield and yield attributing characters viz., number of branches plant-1, dry matter accumulation plant', number of flowers plant', number of capsules plant-1, grain yield plant-1, test weight and seed yield (kg ha-1) but the plant height was higher in no terminal bud nipping and no salicylic acid spray. GMR, NMR and B:C ratio were significantly more in the treatments of terminal bud nipping at 35 DAS (2.48) and 100 ppm spray of salicylic acid at 35 and 50 DAS (2.71). (Key words: Sesame, nipping, salicylic acid, growth and yield)